BEL/Pao retrotransposons in metazoan genomes

Decoding Noncoding Regulatory DNAs in Metazoan Genomes

The recent revelation that the human genome contains only ~30,000 genes underscores the importance of gene regulation in generating organismal diversity. Cis-regulatory DNAs, or enhancers, are short stretches of DNA--300 bp to 1,000 bp in length--that control gene expression. This DNA accounts for a substantial fraction of metazoan genomes, but is largely invisible. It cannot be identified by s...

Rolling circle amplification of metazoan mitochondrial genomes.

Helitrons and Retrotransposons Are Co-localized in Bos taurus Genomes

BACKGROUND DNA transposons helitrons are mobile genetic elements responsible for major movements of the genetic material within and across different genomes. This ability makes helitrons suitable candidate elements for the development of new approaches of multilocus genotyping of live-stock animals, along with the well-known microsatellite loci. OBJECTIVE We aimed to estimate the informativen...

miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes

MicroRNAs (miRNAs) are small non-coding RNA molecules that can negatively regulate gene expression and thus control numerous cellular mechanisms. This work develops a resource, miRNAMap 2.0, for collecting experimentally verified microRNAs and experimentally verified miRNA target genes in human, mouse, rat and other metazoan genomes. Three computational tools, miRanda, RNAhybrid and TargetScan,...

Telomerase and retrotransposons: reverse transcriptases that shaped genomes.

Department of Biological Sciences and RNA Institute, University at Albany, State University of New York, Albany, NY 12222; Wadsworth Center, New York State Department of Health, Albany, NY 12201-2002; Department of Biomedical Sciences, University at Albany, State University of New York, Albany, NY 12222; and Department of Microbiology and Immunology, W. R. Hearst Microbiology Research Center, W...